Tourette Syndrome: A Review of Lifetime Clinical Course and Psychosocial Implications
DOI:
https://doi.org/10.35365/cjhs.26.1.07Keywords:
Tourette syndrome, Lifetime course, Psychosocial functioningAbstract
The aim of this review is to examine the history, clinical features, and lifelong course of Tourette's syndrome, thereby contributing to an understanding of the symptoms that emerge from childhood to adulthood and the difficulties associated with this syndrome. The study addresses the definition, prevalence, typical tics, comorbid conditions (particularly attention deficit hyperactivity disorder and obsessive-compulsive disorder), and lifelong course of Tourette's syndrome. According to the literature, Tourette's syndrome is most commonly seen in school-aged children, and the severity and presentation of tics may change over time. This can affect social relationships, school performance, and psychosocial functioning and may increase the risk of depression. Prevalence peaks in the pre-adolescent period, with symptoms diminishing in approximately half of cases by early adulthood, while comorbid conditions persist in some cases. A review of the literature reveals that new studies on Tourette's syndrome are limited. This review synthesizes multiple studies and emphasizes that appropriate diagnostic and treatment approaches can improve the quality of life and psychosocial functioning of affected children. The study aims to provide an up-to-date perspective on the clinical management of Tourette's syndrome and to advance understanding of this important neurological disorder that affects individuals' lives.
References
Akgüloğlu, F. (1998). Gilles de la Tourette sendromu olan çocuk ve gençlerin biyopsikososyal özellikleri (Tıpta uzmanlık tezi). Çukurova Üniversitesi. Retrieved February 1, 2026, from
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, ed 5. Washington DC, APA Press. https://doi.org/10.1176/appi.books.9780890425596
Bloch, M., Landeros-Weisenberger, A., Johnson, J., & Leckman, J. (2021). A Phase-2 Pilot Study of a Therapeutic Combination of Δ9-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette's Syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 33(4), 328-336.
https://doi.org/10.1176/appi.neuropsych.19080178.
Billnitzer, A., & Jankovic, J. (2020). Current management of tics and Tourette syndrome: behavioral, pharmacologic, and surgical treatments. Neurotherapeutics, 17(4), 1681-1693.
https://doi.org/10.1007/s13311-020-00914-6.
Breton, Z., Denis, P., Goussé, V., & Hartmann, A. (2025). The diagnostic and therapeutic journey of Tourette syndrome: Thematic analysis of the difficulties experienced by parents of patients. Revue Neurologique, 181(6), 544-555.
https://doi.org/10.1016/j.neurol.2025.03.011.
Burd, L., Kerbeshian, J., Wikenheiser, M., & Fisher, W. (1986). Prevalence of Gilles de la Tourette's syndrome in North Dakota adults. The American Journal of Psychiatry, 143(6), 787-788. https://doi.org/10.1176/ajp.143.6.787.
Burd, L., Kerbeshian, J., Barth, A., Klug, M. G., Avery, K., & Benz, B. (2001). Long-term follow-up of an epidemiologically defined cohort of patients with Tourette syndrome. Journal of Child Neurology, 16(6), 431-437.
https://doi.org/10.1177/088307380101600609.
Curtis-Wendlandt, L., & Reynolds, J. (2021). Why Tourette Syndrome Research Needs Philosophical Phenomenology. Phenomenology and the Cognitive Sciences, 20(4), 573-600. https://doi.org/10.1007/s11097-020-09688-w
Deeb, W., Leentjens, A., Mogilner, A., Servello, D., Meng, F., Zhang, J., Okuna, M. (2020). Deep Brain Stimulation Lead Removal in Tourette Syndrome. Parkinsonism and Related Disorders, 89-93.
https://doi.org/10.1016/j.parkreldis.2020.06.025.
Drury, H., Channon, S., Barrett, R., Young, M.-B., Stern, J., Simmons, H., & Crawford, S. (2012). Emotional Processing and Executive Functioning in Children And Adults With Tourette's Syndrome. Child Neuropsychology, 18(3), 281-298.
https://doi.org/10.1080/09297049.2011.613811.
Erbilgin, S. (2016). Çocuk ve Ergenlik Dönemi Tourette Bozukluğunda Eşlik Eden Psikiyatrik Tanılar, Aile Özellikleri ve Yaşam Kalitesi. İstanbul Üniversitesi, 2. İstanbul, Türkiye.
Erol, A. (2022). Derleme Yazmanın Temel İlkeleri. Nöro Psikiyatri Arşivi, 59, 1-2. https://doi.org/10.29399/npa.28093
Eisenhauer, J., Buckland, A., Watson, S., & Stell, R. (2025). Combined habit reversal therapy and acceptance and commitment therapy for treatment of tics in Tourette syndrome: A pilot study of effectiveness and response duration. Movement Disorders Clinical Practice, 12(1), 66-70.
https://doi.org/10.1002/mdc3.14260.
Fatih, P., Mutluer, T., Shabsog, M., Capaci, M., Necef, I., Taşkıran, S., & Yorulmaz, C. (2020). Socio-legal Consequences of Tourette Syndrome And Its Comorbidities: A Case Study And Review of The Literature. Journal of Forensic and Legal Medicine, 71(101937).
https://doi.org/10.1016/j.jflm.2020.101937.
Hollis, C., Pennant, M., Cuenca, J., Glazebrook, C., Kendall, T., Whittington, C., ... & Stern, J. (2016). Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technology Assessment (Winchester, England), 20(4),1.
https://doi.org/10.3310/hta20040.
Imbriglio, T. V., Labelle, V., Thibault, G., O'Connor, K. P., Stip, E., & Lavoie, M. E. (2008). Electrophysiological and neuropsychological effects of cognitive-behavioral therapy on Tourette syndrome. Brain and Cognition, 67, S22-S23. https://doi.org/10.1016/j.bandc.2008.02.042.
Jankovic, J., Gelineau‐Kattner, R., & Davidson, A. (2010). Tourette’s Syndrome in Adults. Movement Disorders Society, 25(13), 2171-2175. https://doi.org/10.1002/mds.23199.
Jiménez-Jiménez, F., Alonso-Navarro, H., García-Martín, E., Agúndez, J., & Agúndez, J. (2020). Sleep Disorders in Tourette Syndrome. Sleep Medicine Reviews, 53, 101335. https://doi.org/10.1016/j.smrv.2020.101335.
Jo, Y. D., Kim, D. J., Hwang, K. S., Jung, C. G., Lee, S. W., Lee, D. H., ... & Yang, C. M. (2025). Meta-analysis of Internet-based Behavior Therapy for Tic Disorder. Clinical Psychopharmacology and Neuroscience, 23(3), 453. https://doi.org/10.9758/cpn.25.1294.
Johnson, K. A., Worbe, Y., Foote, K. D., Butson, C. R., Gunduz, A., & Okun, M. S. (2023). Tourette syndrome: clinical features, pathophysiology, and treatment. The Lancet Neurology, 22(2), 147-158. https://doi.org/10.1016/S1474-4422(22)00303-9.
Kim, S., Jackson, G., Dyke, K., & Jackson, S. (2019). Impaired Forward Model Updating in Young Adults with Tourette Syndrome. Brain, 142(1), 209-219.
https://doi.org/10.1093/brain/awy306.
Kim, D., Warburton, D., Wu, N., Barr, A., Honer, W., & Procyshyn, R. (2018). Effects Of Physical Activity On The Symptoms Of Tourette Syndrome: A Systematic Review. European Psychiatry, 48(1), 13-19., 48(1), 13-19. https://doi.org/10.1016/j.eurpsy.2017.11.002.
Lang, A., Consky, E., & Sandor, P. (1993). “Signing Tics” - Insights into the Pathophysiology of Symptoms in Tourette’s Syndrome. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 33(2), 212-215. https://doi.org/10.1002/ana.410330212.
Leckman, J. (2002). Tourette's Syndrome. The Lancet, 360(9345), 1577- 1586. https://doi.org/10.1016/S0140-6736(02)11526-1.
Lee, M.-Y., Wang, H.-S., & Lee, T.-Y. (2022). Psychosocial Stress, Self-esteem, and Social Adjustment: A moderated Mediation Analysis in Taiwanese Adolescents With Tourette Syndrome. Journal of Pediatric Nursing, 62, 84-90. https://doi.org/10.1016/j.pedn.2021.07.013.
Lichter, D., & Finnegan, S. (2015). Influence of Gender on Tourette Syndrome Beyond Adolescence. European Psychiatry, 30(2). https://doi.org/10.1016/j.eurpsy.2014.07.003.
Liu Z-S, Cui Y-H, Sun D, Lu Q, Jiang Y-W, Jiang L, Wang J-Q, Luo R, Fang F, Zhou S-Z, Wang Y, Cai F-C, Lin Q, Xiong L, Zheng Y, and Qin J (2020). Current Status, Diagnosis, and Treatment Recommendation for Tic Disorders in China. Frontiers in Psychiatry, 11, 774. https://doi.org/10.3389/fpsyt.2020.00774.
Małek, A., & Golińska, P. (2020). Depression in Tourette Syndrome. Psychiatria Polska (54), 69-82.
https://doi.org/10.12740/PP/OnlineFirst/94471.
Morand-Beaulieu, S., Zhong, J., Ibrahim, K., Crowley, M. J., Grantz, H., Leckman, J. F., & Sukhodolsky, D. G. (2025).
Electroencephalographic Functional Connectivity Patterns in Children With Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder. Pediatric Neurology, 172, 53-62. https://doi.org/10.1016/j.pediatrneurol.2025.08.001
Nomura, Y. (2022). Pharmacological Therapy for Tourette Syndrome: What Medicine Can Do and Cannot Do. Biomedical Journal, 45, 229-239. https://doi.org/10.1016/j.bj.2021.09.002.
Ohta, M., & Kano, Y. (2003). Clinical Characteristics of Adult Patients With Tics and/or Tourette’s Syndrome. Brain and Development, 25, 32-36. https://doi.org/10.1016/s0387-7604(03)90006-4.
Reese, H. E., Brown, W. A., Wallenberger, Y. H., Ramsey, K. A., Browning, L. E., Rooks, J., ... & McGuire, J. F. (2026). Remote delivery of a mindfulness-based intervention for adults with tics: Protocol of a randomized controlled trial. Contemporary Clinical Trials, 108224. https://doi.org/10.1016/j.cct.2026.108224
Schlander, M., Schwarz, O., Rothenberger, A., & Roessner, V. (2011). Tic disorders: administrative prevalence and co-occurrence with attention-deficit/hyperactivity disorder in a German community sample. European Psychiatry, 26(6), 370-374.4(3), 149-159.
https://doi.org/10.1016/j.eurpsy.2009.10.003.
Singer, H. S. (2005). Tourette's Syndrome: From Behavior to Biology. The Lancet Neurology, 4(3), 149-159. https://doi.org/10.1016/S1474-4422(05)01012-4.
Tan, C. Y., Chiu, N. C., Zeng, Y. H., Huang, J. Y., Tzang, R. F., Chen, H. J., ... & Ho, C. S. (2024). Psychosocial stress in children with Tourette syndrome and chronic tic disorder. Pediatrics & Neonatology, 65(4), 336-340.
https://doi.org/10.1016/j.pedneo.2023.06.011
Woods, D. W., Himle, M. B., & Conelea, C. A. (2006). Behavior therapy: Other interventions. In D. W. Woods & J. Piacentini (Eds.), Tourette syndrome (pp. 99–234). Oxford University Press. ISBN-13: 978-0195341287
Wu, C.-C., Wong, L.C., Hsu, C.-J., Yang, C.W., Tsai, Y.C., Cheng, F.S., Lee, W.-T. (2021). Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome. Nutrients, 13(11), 3698. https://doi.org/10.3390/nu13113698.
Yıldırım, Z. G. (2015). Kronik tik bozukluğu ve Tourette sendromu tanısı konan çocuk ve ergenlerde regülatör T hücre düzeyleri ve semptom alevlenmeleri ile ilişkisinin incelenmesi (Tıpta uzmanlık tezi). Ondokuz Mayıs University. Retrieved February 1, 2026,
fromhttps://acikerisim.omu.edu.tr/entities/publication/de7b86f2-ce34-42ab-a3b0-ff644451efa3
Yue, Y. A. N. G. (2024). Plum-blossom needle therapy for Tourette syndrome: A case report. Explore, 20(3), 456-459. https://doi.org/10.1016/j.explore.2023.09.010.
Zinner Samuel H.(2000). Tourette Disorder. Pediatric Reviews, 21(11) 372–383. https://doi.org/10.1542/pir.21-11-372
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Melis Özçağlı, Meryem Karaaziz

This work is licensed under a Creative Commons Attribution 4.0 International License.